The COVID-19 pandemic and its mitigation measures have created an extra burden for grass-roots organizations and the communities they serve. Although ensuring sustainability of their programmatic work and finding innovative ways to meet the diverse needs of the families and children, especially of those living in vulnerable and adverse contexts, have always been at the core of their everyday work, the shock caused by COVID-19 is unprecedented in terms of speed, scope, and intensity. ISSA Members have been proactive in tackling the challenges of the pandemic at the institution/program level but also at the level of the populations they serve. This brief provides an overview of ways in which five ISSA Members across Europe have responded to limit the impact of COVID-19 on the most vulnerable people they serve.